Rigor and Reproducibility

Johns Hopkins University students in a laboratory. (Johns Hopkins University Photo)

Two of the cornerstones of science advancement are rigor in
designing and performing scientific research and the ability to
reproduce biomedical research findings. The application of rigor ensures
robust and unbiased experimental design, methodology, analysis,
interpretation, and reporting of results. When a result can be
reproduced by multiple scientists, it validates the original results and
readiness to progress to the next phase of research. This is especially
important for clinical trials in humans, which are built on studies
that have demonstrated a particular effect or outcome.


In recent years, however, there has been a growing awareness of
the need for rigorously designed published preclinical studies, to
ensure that such studies can be reproduced. This webpage provides
information about the efforts underway by NIH to enhance rigor and
reproducibility in scientific research.

Richard Siegel, M.D., Ph.D., (right) NIAMS
Clinical Director and Chief of the Autoimmunity Branch, discusses
research results with postdoctoral fellow Martin Pelletier, Ph.D. (Bill
Branson, photographer)